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Potent, Selective, and Cell-Penetrating Inhibitors of Kallikrein-Related Peptidase 4 Based on the Cyclic Peptide MCoTI-II

[Image: see text] Kallikrein-related peptidase 4 (KLK4) is a serine protease that has putative intracellular and extracellular functions in prostate cancer progression. Here we show that MCoTI-II, a 34-amino acid cyclic peptide found in the seeds of red gac (Momordica cochinchinensis), is an inhibit...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Swedberg, Joakim E., Ghani, Hafiza Abdul, Harris, Jonathan M., de Veer, Simon J., Craik, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295872/
https://ncbi.nlm.nih.gov/pubmed/30613336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00422
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