Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis

Silicosis is pneumoconiosis of the lung, usually resulting from prolonged exposure to crystalline silica (CS). The hallmark of silicosis is excessive extracellular matrix (ECM) deposition produced by activated fibroblasts. Recent work demonstrated that excessive ECM-forming mechanical cues play an e...

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Bibliografiske detaljer
Udgivet i:Theranostics
Main Authors: Li, Siyi, Li, Chao, Zhang, Yiting, He, Xiu, Chen, Xi, Zeng, Xinning, Liu, Fangwei, Chen, Ying, Chen, Jie
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691376/
https://ncbi.nlm.nih.gov/pubmed/31410197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.35665
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