4-1BB Signaling Promotes Alveolar Macrophages-Mediated Pro-Fibrotic Responses and Crystalline Silica-Induced Pulmonary Fibrosis in Mice

Silicosis is caused by exposure to crystalline silica (CS). We have previously shown that blocking 4-1BB signaling attenuated CS-induced inflammation and pulmonary fibrosis. However, the cells that express 4-1BB, which plays a vital role in promoting fibrosis, are still unknown. In this study, we de...

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Vydáno v:Front Immunol
Hlavní autoři: Lu, Yiping, Li, Chao, Du, Sitong, Chen, Xi, Zeng, Xinning, Liu, Fangwei, Chen, Ying, Chen, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139304/
https://ncbi.nlm.nih.gov/pubmed/30250465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01848
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