Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis

Silicosis is pneumoconiosis of the lung, usually resulting from prolonged exposure to crystalline silica (CS). The hallmark of silicosis is excessive extracellular matrix (ECM) deposition produced by activated fibroblasts. Recent work demonstrated that excessive ECM-forming mechanical cues play an e...

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Bibliographische Detailangaben
Veröffentlicht in:Theranostics
Hauptverfasser: Li, Siyi, Li, Chao, Zhang, Yiting, He, Xiu, Chen, Xi, Zeng, Xinning, Liu, Fangwei, Chen, Ying, Chen, Jie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691376/
https://ncbi.nlm.nih.gov/pubmed/31410197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.35665
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