Myeloid maturation potentiates STAT3-mediated atypical IFN-γ signaling and upregulation of PD-1 ligands in AML and MDS

Interferon (IFN)-γ is the major mediator of anti-tumor immune responses; nevertheless, cancer cells use intrigue strategies to alter IFN-γ signaling and avoid elimination. Understanding the immune regulatory mechanisms employed by acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) cells...

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Publicado no:Sci Rep
Main Authors: Yoyen-Ermis, Digdem, Tunali, Gurcan, Tavukcuoglu, Ece, Horzum, Utku, Ozkazanc, Didem, Sutlu, Tolga, Buyukasik, Yahya, Esendagli, Gunes
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691003/
https://ncbi.nlm.nih.gov/pubmed/31406210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48256-4
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