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Link clustering explains non-central and contextually essential genes in protein interaction networks

Recent studies have shown that many essential genes (EGs) change their essentiality across various contexts. Finding contextual EGs in pathogenic conditions may facilitate the identification of therapeutic targets. We propose link clustering as an indicator of contextual EGs that are non-central in...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Kim, Inhae, Lee, Heetak, Lee, Kwanghwan, Han, Seong Kyu, Kim, Donghyo, Kim, Sanguk
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690968/
https://ncbi.nlm.nih.gov/pubmed/31406201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48273-3
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