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Link clustering explains non-central and contextually essential genes in protein interaction networks

Recent studies have shown that many essential genes (EGs) change their essentiality across various contexts. Finding contextual EGs in pathogenic conditions may facilitate the identification of therapeutic targets. We propose link clustering as an indicator of contextual EGs that are non-central in...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Kim, Inhae, Lee, Heetak, Lee, Kwanghwan, Han, Seong Kyu, Kim, Donghyo, Kim, Sanguk
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690968/
https://ncbi.nlm.nih.gov/pubmed/31406201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48273-3
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