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Link clustering explains non-central and contextually essential genes in protein interaction networks

Recent studies have shown that many essential genes (EGs) change their essentiality across various contexts. Finding contextual EGs in pathogenic conditions may facilitate the identification of therapeutic targets. We propose link clustering as an indicator of contextual EGs that are non-central in...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kim, Inhae, Lee, Heetak, Lee, Kwanghwan, Han, Seong Kyu, Kim, Donghyo, Kim, Sanguk
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690968/
https://ncbi.nlm.nih.gov/pubmed/31406201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48273-3
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