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Atorvastatin increases the production of proinflammatory cytokines and decreases the survival of Escherichia coli-infected mice

To assess whether the immunosuppressive effects of atorvastatin outweigh its antibacterial ones in an infection, mice were infected with Escherichia coli and administered atorvastatin; survival rates were then monitored. Mice treated with atorvastatin post-infection showed a remarkable decrease in t...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hussein, Hadi M., Al-Khoury, Diva Kalash, Abdelnoor, Alexander M., Rahal, Elias A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690901/
https://ncbi.nlm.nih.gov/pubmed/31406240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48282-2
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