Aurora-A/ERK1/2/mTOR axis promotes tumor progression in triple-negative breast cancer and dual-targeting Aurora-A/mTOR shows synthetic lethality

Triple-negative breast cancer (TNBC), defined as a tumor subtype that lacks ER, PR, and HER2, shows a poor prognosis due to its aggressive tumor biology and limited treatment options. Deregulation of Aurora kinase A (Aur-A), a member of the mitotic serine/threonine Aurora kinase family, and overacti...

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Pubblicato in:Cell Death Dis
Autori principali: Zhang, Wenfeng, Xia, Ding, Li, Zhangyun, Zhou, Tao, Chen, Tingting, Wu, Zhengping, Zhou, Weihua, Li, Zilun, Li, Longkun, Xu, Jie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690898/
https://ncbi.nlm.nih.gov/pubmed/31406104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1855-z
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