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Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis
Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms including oxidative stress and glutamate toxicity, and occurs in...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6690882/ https://ncbi.nlm.nih.gov/pubmed/31406150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48087-3 |
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