The NEDD8-activating enzyme inhibitor MLN4924 sensitizes a TNFR1(+) subgroup of multiple myeloma cells for TNF-induced cell death

The NEDD8-activating enzyme (NAE) inhibitor MLN4924 inhibits cullin-RING ubiquitin ligase complexes including the SKP1-cullin-F-box E3 ligase βTrCP. MLN4924 therefore inhibits also the βTrCP-dependent activation of the classical and the alternative NFĸB pathway. In this work, we found that a subgrou...

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Vydáno v:Cell Death Dis
Hlavní autoři: El-Mesery, Mohamed, Rosenthal, Tina, Rauert-Wunderlich, Hilka, Schreder, Martin, Stühmer, Thorsten, Leich, Ellen, Schlosser, Andreas, Ehrenschwender, Martin, Wajant, Harald, Siegmund, Daniela
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690881/
https://ncbi.nlm.nih.gov/pubmed/31406107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1860-2
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