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Exploring small molecules with pan-genotypic inhibitory activities against hepatitis C virus NS3/4A serine protease

Among the many Hepatitis C virus (HCV) genotypes and subtypes, genotypes 1b and 3a are most prevalent in United States and Asia, respectively. A total of 132 commercially available analogs of a previous lead compound were initially investigated against wild-type HCV genotype 1b NS3/4A protease. Ten...

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Bibliografische gegevens
Gepubliceerd in:Bioorg Med Chem Lett
Hoofdauteurs: Ren, Jinhong, Ojeda, Isabel, Patel, Maulik, Johnson, Michael E., Lee, Hyun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690791/
https://ncbi.nlm.nih.gov/pubmed/31201062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.06.009
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