Molecular and Cellular Studies Evaluating a Potent 2-Cyanoindolizine Catechol Diether NNRTI Targeting Wildtype and Y181C Mutant HIV-1 Reverse Transcriptase

The development of efficacious NNRTIs for HIV/AIDS therapy is commonly met with the emergence of drug resistant strains, including the Y181C variant. Using a computationally-guided approach, we synthesized the catechol diether series of NNRTIs, which display sub-nanomolar potency in cellular assays....

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I publikationen:Bioorg Med Chem Lett
Huvudupphovsmän: Sasaki, Tomoaki, Gannam, Zira T.K., Kudalkar, Shalley N., Frey, Kathleen M., Lee, Won-Gil, Spasov, Krasimir A., Jorgensen, William L., Anderson, Karen S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690785/
https://ncbi.nlm.nih.gov/pubmed/31281023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.06.047
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