Structural and biochemical characterization of 20β-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32

Anaerobic bacteria inhabiting the human gastrointestinal tract have evolved various enzymes that modify host-derived steroids. The bacterial steroid-17,20-desmolase pathway cleaves the cortisol side chain, forming pro-androgens predicted to impact host physiology. Bacterial 20β-hydroxysteroid dehydr...

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Udgivet i:J Biol Chem
Main Authors: Doden, Heidi L., Pollet, Rebecca M., Mythen, Sean M., Wawrzak, Zdzislaw, Devendran, Saravanan, Cann, Isaac, Koropatkin, Nicole M., Ridlon, Jason M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2019
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690682/
https://ncbi.nlm.nih.gov/pubmed/31209107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009390
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