Chronic intrauterine hypoxia alters neurodevelopment in fetal sheep

OBJECTIVE: We tested the hypothesis that chronic fetal hypoxia, at a severity present in many types of congenital heart disease, would lead to abnormal neurodevelopment. METHODS: Eight mid-gestation fetal sheep were cannulated onto a pumpless extracorporeal oxygenator via the umbilical vessels and s...

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Pubblicato in:J Thorac Cardiovasc Surg
Autori principali: Lawrence, Kendall M., McGovern, Patrick E., Mejaddam, Ali, Rossidis, Avery C., Baumgarten, Heron, Kim, Aimee, Grinspan, Judith B., Licht, Daniel J., Didier, Ryne A., Vossough, Arastoo, Radaelli, Enrico, Rychik, Jack, Song, Limei, Peranteau, William H., Davey, Marcus G., Flake, Alan W., Gaynor, J. William
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690589/
https://ncbi.nlm.nih.gov/pubmed/30745051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2018.12.093
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