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The power of multiplexed functional analysis of genetic variants

New technologies have recently enabled saturation mutagenesis and functional analysis of nearly all possible variants of regulatory elements or proteins of interest in single experiments. Here we discuss the past, present, and futureof such multiplexed (functional) assays for variant effects (MAVEs)...

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Bibliografische gegevens
Gepubliceerd in:Nat Protoc
Hoofdauteurs: Gasperini, Molly, Starita, Lea, Shendure, Jay
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690347/
https://ncbi.nlm.nih.gov/pubmed/27583640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2016.135
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