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The power of multiplexed functional analysis of genetic variants

New technologies have recently enabled saturation mutagenesis and functional analysis of nearly all possible variants of regulatory elements or proteins of interest in single experiments. Here we discuss the past, present, and futureof such multiplexed (functional) assays for variant effects (MAVEs)...

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Bibliografski detalji
Izdano u:Nat Protoc
Glavni autori: Gasperini, Molly, Starita, Lea, Shendure, Jay
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690347/
https://ncbi.nlm.nih.gov/pubmed/27583640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2016.135
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