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Targeting MDM2-p53 Interaction for Cancer Therapy: Are We There Yet?

Inactivation of the tumor suppressor p53 and/or overexpression of the oncogene MDM2 frequently occur in human cancers, and are associated with poor prognosis, advanced forms of the disease, and chemoresistance. MDM2, the major negative regulator of p53, induces p53 degradation and inactivates its tu...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Curr Med Chem
Prif Awduron: Nag, S., Zhang, X., Srivenugopal, K.S., Wang, M.-H., Wang, W., Zhang, R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690199/
https://ncbi.nlm.nih.gov/pubmed/24180275
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