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Preclinical pharmacology of novel indolecarboxamide ML-970, an investigative anticancer agent
PURPOSE: ML-970 (AS-I-145; NSC 716970) is an indolecarboxamide synthesized as a less toxic analog of CC-1065 and duocarmycin, a natural product that binds the A-T-rich DNA minor groove and alkylates DNA. The NCI60 screening showed that ML-970 had potent cytotoxic activity, with an average GI(50) of...
Gorde:
| Argitaratua izan da: | Cancer Chemother Pharmacol |
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| Egile Nagusiak: | , , , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2012
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6690187/ https://ncbi.nlm.nih.gov/pubmed/22367116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1851-9 |
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