Preclinical pharmacology of novel indolecarboxamide ML-970, an investigative anticancer agent

PURPOSE: ML-970 (AS-I-145; NSC 716970) is an indolecarboxamide synthesized as a less toxic analog of CC-1065 and duocarmycin, a natural product that binds the A-T-rich DNA minor groove and alkylates DNA. The NCI60 screening showed that ML-970 had potent cytotoxic activity, with an average GI(50) of...

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Gepubliceerd in:Cancer Chemother Pharmacol
Hoofdauteurs: Rayburn, Elizabeth, Wang, Wei, Li, Mao, Zhang, Xu, Xu, Hongxia, Li, Haibo, Qin, Jiang-Jiang, Jia, Lee, Covey, Joseph, Lee, Moses, Zhang, Ruiwen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690187/
https://ncbi.nlm.nih.gov/pubmed/22367116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-012-1851-9
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