Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration

Repair of degenerated intervertebral discs (IVD) might be established via intradiscal delivery of biologic therapies. Polyester amide polymers (PEA) were evaluated for in vitro cytotoxicity and in vivo biocompatibility, and thereafter intradiscal application of PEA microspheres (PEAMs) in a canine m...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biomed Mater Res B Appl Biomater
Auteurs principaux: Willems, Nicole, Mihov, George, Grinwis, Guy C.M., van Dijk, Maarten, Schumann, Detlef, Bos, Clemens, Strijkers, Gustav J., Dhert, Wouter J.A., Meij, Björn P., Creemers, Laura B., Tryfonidou, Marianna A.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
Sujets:
Original Research Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690078/
https://ncbi.nlm.nih.gov/pubmed/26687460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.b.33579
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