B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes

Previous studies indicate that B-lymphocytes play a key role activating diabetogenic T-lymphocytes during the development of autoimmune diabetes. Recently, two transgenic NOD mouse models were generated: the NOD-PerIg and the 116C-NOD mice. In NOD-PerIg mice, B-lymphocytes acquire an activated proli...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Egia-Mendikute, Leire, Arpa, Berta, Rosell-Mases, Estela, Corral-Pujol, Marta, Carrascal, Jorge, Carrillo, Jorge, Mora, Conchi, Chapman, Harold, Panosa, Anaïs, Vives-Pi, Marta, Stratmann, Thomas, Serreze, David, Verdaguer, Joan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689997/
https://ncbi.nlm.nih.gov/pubmed/31428087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01732
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