Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the K(ATP)/MAPK pathway

Endothelial dysfunction is a key risk factor in diabetes-related multiorgan damage. Methylglyoxal (MGO), a highly reactive dicarbonyl generated primarily as a by-product of glycolysis, is increased in both type 1 and type 2 diabetic patients. MGO can rapidly bind with proteins, nucleic acids, and li...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Wang, Yihan, Hall, Leo M., Kujawa, Marisa, Li, Hainan, Zhang, Xiang, O’Meara, Megan, Ichinose, Tomomi, Wang, Jie-Mei
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689756/
https://ncbi.nlm.nih.gov/pubmed/30995106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00117.2018
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