Differential thermostability and response to cystic fibrosis transmembrane conductance regulator potentiators of human and mouse F508del-CFTR

Cross-species comparative studies have highlighted differences between human and mouse cystic fibrosis transmembrane conductance regulator (CFTR), the epithelial Cl(−) channel defective in cystic fibrosis (CF). Here, we compare the impact of the most common CF mutation F508del on the function of hum...

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Publicat a:Am J Physiol Lung Cell Mol Physiol
Autors principals: Bose, Samuel J., Bijvelds, Marcel J. C., Wang, Yiting, Liu, Jia, Cai, Zhiwei, Bot, Alice G. M., de Jonge, Hugo R., Sheppard, David N.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2019
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689747/
https://ncbi.nlm.nih.gov/pubmed/30969810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00034.2019
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