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A chaperone lid ensures efficient and privileged client transfer during tail-anchored protein targeting

Molecular chaperones play key roles in maintaining cellular proteostasis. In addition to preventing client aggregation, chaperones often relay substrates within a network while preventing off-pathway chaperones from accessing the substrate. Here we show that a conserved lid motif lining the substrat...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Chio, Un Seng, Chung, SangYoon, Weiss, Shimon, Shan, Shu-ou
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689467/
https://ncbi.nlm.nih.gov/pubmed/30605684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.12.035
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