PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer

Overcoming cellular growth restriction, including the evasion of cellular senescence, is a hallmark of cancer. We report that PAK4 is overexpressed in all human breast cancer subtypes and associated with poor patient outcome. In mice, MMTV-PAK4 overexpression promotes spontaneous mammary cancer, whi...

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Publicado no:Nat Commun
Main Authors: Costa, Tânia D. F., Zhuang, Ting, Lorent, Julie, Turco, Emilia, Olofsson, Helene, Masia-Balague, Miriam, Zhao, Miao, Rabieifar, Parisa, Robertson, Neil, Kuiper, Raoul, Sjölund, Jonas, Spiess, Matthias, Hernández-Varas, Pablo, Rabenhorst, Uta, Roswall, Pernilla, Ma, Ran, Gong, Xiaowei, Hartman, Johan, Pietras, Kristian, Adams, Peter D., Defilippi, Paola, Strömblad, Staffan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689091/
https://ncbi.nlm.nih.gov/pubmed/31399573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11510-4
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