PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer

Overcoming cellular growth restriction, including the evasion of cellular senescence, is a hallmark of cancer. We report that PAK4 is overexpressed in all human breast cancer subtypes and associated with poor patient outcome. In mice, MMTV-PAK4 overexpression promotes spontaneous mammary cancer, whi...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Costa, Tânia D. F., Zhuang, Ting, Lorent, Julie, Turco, Emilia, Olofsson, Helene, Masia-Balague, Miriam, Zhao, Miao, Rabieifar, Parisa, Robertson, Neil, Kuiper, Raoul, Sjölund, Jonas, Spiess, Matthias, Hernández-Varas, Pablo, Rabenhorst, Uta, Roswall, Pernilla, Ma, Ran, Gong, Xiaowei, Hartman, Johan, Pietras, Kristian, Adams, Peter D., Defilippi, Paola, Strömblad, Staffan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689091/
https://ncbi.nlm.nih.gov/pubmed/31399573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11510-4
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker