Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies

Obtaining full-length antibody heavy- and light-chain variable regions from individual B cells at scale remains a challenging problem. Here we use high-throughput single-cell B-cell receptor sequencing (scBCR-seq) to obtain accurately paired full-length variable regions in a massively parallel fashi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Commun Biol
Prif Awduron: Goldstein, Leonard D., Chen, Ying-Jiun J., Wu, Jia, Chaudhuri, Subhra, Hsiao, Yi-Chun, Schneider, Kellen, Hoi, Kam Hon, Lin, Zhonghua, Guerrero, Steve, Jaiswal, Bijay S., Stinson, Jeremy, Antony, Aju, Pahuja, Kanika Bajaj, Seshasayee, Dhaya, Modrusan, Zora, Hötzel, Isidro, Seshagiri, Somasekar
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689056/
https://ncbi.nlm.nih.gov/pubmed/31428692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0551-y
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