CDK7 inhibitor THZ1 inhibits MCL1 synthesis and drives cholangiocarcinoma apoptosis in combination with BCL2/BCL-XL inhibitor ABT-263

Cholangiocarcinoma (CCA) is a fatal disease without effective targeted therapy. We screened a small-molecule library of 116 inhibitors targeting different targets of the cell cycle and discovered several kinases, including Cyclin-dependent kinase 7 (CDK7) as vulnerabilities in CCA. Analysis of multi...

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Publicat a:Cell Death Dis
Autors principals: Huang, Tianlu, Ding, Xiwei, Xu, Guifang, Chen, Gang, Cao, Yu, Peng, Chunyan, Shen, Shanshan, Lv, Ying, Wang, Lei, Zou, Xiaoping
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688996/
https://ncbi.nlm.nih.gov/pubmed/31399555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1831-7
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