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Asymmetric Chemoenzymatic Synthesis of (–)-Podophyllotoxin and Related Aryltetralin Lignans
(–)-Podophyllotoxin is one of the most potent microtubule depolymerizing agents and has served as an important lead compound in antineoplastic drug discovery. Here, we report a short chemoenzymatic total synthesis of (–)-podophyllotoxin and related aryltetralin lignans. Vital to this approach is the...
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| izdano v: | Angew Chem Int Ed Engl |
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| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6688964/ https://ncbi.nlm.nih.gov/pubmed/31241812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201904102 |
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