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Efficient Chemoenzymatic Synthesis of (2S,3R)-3-Hydroxy-3-Methylproline, a Key Fragment in Polyoxypeptin A and FR225659

We report an efficient synthesis of protected (2S,3R)-3-hydroxy-3-methylproline that proceeds in three steps with complete stereoselectivity. This route represents a significant improvement over previous approaches to this noncanonical amino acid. Key to this success is the development of a one-pot...

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Detalhes bibliográficos
Publicado no:Tetrahedron
Main Authors: Zhang, Xiao, Renata, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934255/
https://ncbi.nlm.nih.gov/pubmed/31885405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2019.04.009
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