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The BEACH Domain Is Critical for Blue Cheese Function in a Spatial and Epistatic Autophagy Hierarchy

Drosophila blue cheese (bchs) encodes a BEACH domain adaptor protein that, like its human homolog ALFY, promotes clearance of aggregated proteins through its interaction with Atg5 and p62. bchs mutations lead to age-dependent accumulation of ubiquitinated inclusions and progressive neurodegeneration...

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Foilsithe in:Front Cell Dev Biol
Main Authors: Sim, Joan, Osborne, Kathleen A., Argudo García, Irene, Matysik, Artur S., Kraut, Rachel
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688705/
https://ncbi.nlm.nih.gov/pubmed/31428609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00129
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