Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants

Sphingolipid metabolites are involved in the regulation of autophagy, a degradative recycling process that is required to prevent neuronal degeneration. Drosophila blue cheese mutants neurodegenerate due to perturbations in autophagic flux, and consequent accumulation of ubiquitinated aggregates. He...

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Udgivet i:Sci Rep
Main Authors: Hebbar, Sarita, Sahoo, Ishtapran, Matysik, Artur, Argudo Garcia, Irene, Osborne, Kathleen Amy, Papan, Cyrus, Torta, Federico, Narayanaswamy, Pradeep, Fun, Xiu Hui, Wenk, Markus R, Shevchenko, Andrej, Schwudke, Dominik, Kraut, Rachel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671070/
https://ncbi.nlm.nih.gov/pubmed/26639035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15926
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