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Crystal structure of the inhibitor-free form of the serine protease kallikrein-4

Kallikrein 4 (KLK4) is a serine protease that is predominantly expressed in the prostate and is overexpressed in prostate cancer. As such, it has gained attention as an attractive target for prostate cancer therapeutics. Currently, only liganded structures of KLK4 exist in the Protein Data Bank. Unt...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Principais autores: Riley, Blake T., Hoke, David E., McGowan, Sheena, Buckle, Ashley M.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688662/
https://ncbi.nlm.nih.gov/pubmed/31397325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X19009610
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