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Solventless and Metal-free Regioselective Hydrofluorination of Functionalized Alkynes and Allenes: An Efficient Protocol for the Synthesis of gem-Difluorides

The combination of two easily handled, highly acidic liquid HF complex reagents, DMPU-12HF and KHSO(4)-13HF, generated a highly acidic fluorination system that facilitated exclusive Markovnikov addition of HF to widely functionalized alkynes, including alkyne tethered drugs, or allenes to produce ge...

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Vydáno v:Green Chem
Hlavní autoři: Lu, Zhichao, Bajwa, Bhvandip S., Liu, Shiwen, Lee, Sheye, Hammond, Gerald B., Xu, Bo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688647/
https://ncbi.nlm.nih.gov/pubmed/31404296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8gc03876g
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