Early Transcriptional Signature in Dendritic Cells and the Induction of Protective T Cell Responses Upon Immunization With VLPs Containing TLR Ligands—A Role for CCL2

Inducing T cell responses by therapeutic vaccination requires appropriate activation of antigen presenting cells (APCs). The use of virus-like particles (VLPs) containing Toll-like receptor (TLR) ligands has demonstrated remarkable potential in activating APCs and modulating the immune response both...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Gomes, Ariane C., Mohsen, Mona O., Mueller, Julius E., Leoratti, Fabiana M. S., Cabral-Miranda, Gustavo, Bachmann, Martin F.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687836/
https://ncbi.nlm.nih.gov/pubmed/31428084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01679
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