Identification of drug-specific public TCR driving severe cutaneous adverse reactions

Drug hypersensitivity such as severe cutaneous adverse reactions (SCAR), including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), could be life-threatening. Here, we enroll SCAR patients to investigate the T cell receptor (TCR) repertoire by next-generation sequencing. A public...

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Pubblicato in:Nat Commun
Autori principali: Pan, Ren-You, Chu, Mu-Tzu, Wang, Chuang-Wei, Lee, Yun-Shien, Lemonnier, Francois, Michels, Aaron W., Schutte, Ryan, Ostrov, David A., Chen, Chun-Bing, Phillips, Elizabeth Jane, Mallal, Simon Alexander, Mockenhaupt, Maja, Bellón, Teresa, Tassaneeyakul, Wichittra, White, Katie D., Roujeau, Jean-Claude, Chung, Wen-Hung, Hung, Shuen-Iu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687717/
https://ncbi.nlm.nih.gov/pubmed/31395875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11396-2
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