BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

PURPOSE: Breast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) risk model to incorporate the effects of polygenic risk scores (PRS) and...

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Gepubliceerd in:Genet Med
Hoofdauteurs: Lee, Andrew, Mavaddat, Nasim, Wilcox, Amber N., Cunningham, Alex P., Carver, Tim, Hartley, Simon, Babb de Villiers, Chantal, Izquierdo, Angel, Simard, Jacques, Schmidt, Marjanka K., Walter, Fiona M., Chatterjee, Nilanjan, Garcia-Closas, Montserrat, Tischkowitz, Marc, Pharoah, Paul, Easton, Douglas F., Antoniou, Antonis C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group US 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687499/
https://ncbi.nlm.nih.gov/pubmed/30643217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-018-0406-9
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