BRCA1 and BRCA2 mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families

INTRODUCTION: Several genetic risk models for breast and ovarian cancer have been developed, but their applicability to specific populations has not been evaluated. We used data from French-Canadian families to evaluate the mutation predictions given by the BRCAPRO and BOADICEA models. We also used...

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Bibliographic Details
Main Authors: Antoniou, Antonis C, Durocher, Francine, Smith, Paula, Simard, Jacques, Easton, Douglas F
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413985/
https://ncbi.nlm.nih.gov/pubmed/16417652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr1365
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