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Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data

Quantification of the effect of spatial tumour sampling on the patterns of mutations detected in next-generation sequencing data is largely lacking. Here we use a spatial stochastic cellular automaton model of tumour growth that accounts for somatic mutations, selection, drift and spatial constraint...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Comput Biol
Egile Nagusiak: Chkhaidze, Ketevan, Heide, Timon, Werner, Benjamin, Williams, Marc J., Huang, Weini, Caravagna, Giulio, Graham, Trevor A., Sottoriva, Andrea
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687187/
https://ncbi.nlm.nih.gov/pubmed/31356595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007243
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