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Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data

Quantification of the effect of spatial tumour sampling on the patterns of mutations detected in next-generation sequencing data is largely lacking. Here we use a spatial stochastic cellular automaton model of tumour growth that accounts for somatic mutations, selection, drift and spatial constraint...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Chkhaidze, Ketevan, Heide, Timon, Werner, Benjamin, Williams, Marc J., Huang, Weini, Caravagna, Giulio, Graham, Trevor A., Sottoriva, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687187/
https://ncbi.nlm.nih.gov/pubmed/31356595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007243
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