Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data

Quantification of the effect of spatial tumour sampling on the patterns of mutations detected in next-generation sequencing data is largely lacking. Here we use a spatial stochastic cellular automaton model of tumour growth that accounts for somatic mutations, selection, drift and spatial constraint...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Comput Biol
Prif Awduron: Chkhaidze, Ketevan, Heide, Timon, Werner, Benjamin, Williams, Marc J., Huang, Weini, Caravagna, Giulio, Graham, Trevor A., Sottoriva, Andrea
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2019
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6687187/
https://ncbi.nlm.nih.gov/pubmed/31356595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007243
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