Formulation of Biocompatible Targeted ECO/siRNA Nanoparticles with Long-Term Stability for Clinical Translation of RNAi

Nanoparticle based siRNA formulations often suffer from aggregation and loss of function during storage. We in this study report a frozen targeted RGD-polyethylene glycol (PEG)-ECO/siβ3 nanoparticle formulation with a prolonged shelf life and preserved nanoparticle functionality. The targeted RGD-PE...

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Detalles Bibliográficos
Publicado en:Nucleic Acid Ther
Main Authors: Ayat, Nadia R., Sun, Zhanhu, Sun, Da, Yin, Michelle, Hall, Ryan C., Vaidya, Amita M., Liu, Xujie, Schilb, Andrew L., Scheidt, Josef H., Lu, Zheng-Rong
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc., publishers 2019
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Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686697/
https://ncbi.nlm.nih.gov/pubmed/31140918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0784
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