PD-1 silencing impairs the anti-tumor function of chimeric antigen receptor modified T cells by inhibiting proliferation activity

BACKGROUND: Blocking programmed death-1 (PD-1) is considered to be a promising strategy to improve T cell function, and this is being explored in many ongoing clinical trials. In fact, our knowledge about PD-1 is primarily based on the results of short-term experiments or observations, but how long-...

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Udgivet i:J Immunother Cancer
Main Authors: Wei, Jianshu, Luo, Can, Wang, Yao, Guo, Yelei, Dai, Hanren, Tong, Chuan, Ti, Dongdong, Wu, Zhiqiang, Han, Weidong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686487/
https://ncbi.nlm.nih.gov/pubmed/31391096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0685-y
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