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Substantial batch effects in TCGA exome sequences undermine pan-cancer analysis of germline variants

BACKGROUND: In recent years, research on cancer predisposition germline variants has emerged as a prominent field. The identity of somatic mutations is based on a reliable mapping of the patient germline variants. In addition, the statistics of germline variants frequencies in healthy individuals an...

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Vydáno v:BMC Cancer
Hlavní autoři: Rasnic, Roni, Brandes, Nadav, Zuk, Or, Linial, Michal
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686424/
https://ncbi.nlm.nih.gov/pubmed/31391007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5994-5
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