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NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model

BACKGROUND/AIMS: Type 1 diabetes (T1D) is characterized by absolute insulin deficiency due to destruction of pancreatic β-cells by cytokines (e.g., interleukin-1β; IL-1β) released by invading immune cells. The mechanisms by which these cytokines induce β-cell dysfunction remain poorly understood. Re...

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Bibliografische gegevens
Gepubliceerd in:Cell Physiol Biochem
Hoofdauteurs: Veluthakal, Rajakrishnan, Sidarala, Vaibhav, Kowluru, Anjaneyulu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6686134/
https://ncbi.nlm.nih.gov/pubmed/27467102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000445666
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