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Computational Prediction of Hot Spots and Binding Site of Inhibitor NSC23766 on Rac1 Binding With Tiam1

Rac1 is a small signaling protein, which belongs to the Rho subfamily of Ras superfamily. It is activated by binding GTP and inactivated by exchanging GDP for GTP. The ability of nucleotide exchange depends on guanine nucleotide exchange factors (GEFs) family proteins. T-lymphoma invasion and metast...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Zheng, Chunwen, Wu, Xiaodong, Zeng, Ruijie, Lin, Lirui, Xu, Liyan, Li, Enmin, Dong, Geng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7884829/
https://ncbi.nlm.nih.gov/pubmed/33604328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.625437
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