The mechanosensitive Piezo1 channel is required for bone formation

Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone formation remains unclear. Here we report that Piezo1, a bona fide mechanotransducer that is...

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Udgivet i:eLife
Main Authors: Sun, Weijia, Chi, Shaopeng, Li, Yuheng, Ling, Shukuan, Tan, Yingjun, Xu, Youjia, Jiang, Fan, Li, Jianwei, Liu, Caizhi, Zhong, Guohui, Cao, Dengchao, Jin, Xiaoyan, Zhao, Dingsheng, Gao, Xingcheng, Liu, Zizhong, Xiao, Bailong, Li, Yingxian
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685704/
https://ncbi.nlm.nih.gov/pubmed/31290742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47454
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