Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling

As a Ca(2+)-activated lipid scramblase and ion channel that mediates Ca(2+) influx, TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood coagulation, and bone formation. How a bona fide ion channel scrambles lipids remains elusive. Our structural analyses revealed t...

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Udgivet i:Cell Rep
Main Authors: Feng, Shengjie, Dang, Shangyu, Han, Tina Wei, Ye, Wenlei, Jin, Peng, Cheng, Tong, Li, Junrui, Jan, Yuh Nung, Jan, Lily Yeh, Cheng, Yifan
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684876/
https://ncbi.nlm.nih.gov/pubmed/31291589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.023
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