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Cryo-EM Studies of TMEM16F Calcium-Activated Ion Channel Suggest Features Important for Lipid Scrambling
As a Ca(2+)-activated lipid scramblase and ion channel that mediates Ca(2+) influx, TMEM16F relies on both functions to facilitate extracellular vesicle generation, blood coagulation, and bone formation. How a bona fide ion channel scrambles lipids remains elusive. Our structural analyses revealed t...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Cell Rep |
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| Κύριοι συγγραφείς: | , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6684876/ https://ncbi.nlm.nih.gov/pubmed/31291589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.06.023 |
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