IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain incompletely defined. By stimulating mouse macrophages with a titration matrix of TLR ligand pairs, we...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Gottschalk, Rachel A, Dorrington, Michael G, Dutta, Bhaskar, Krauss, Kathleen S, Martins, Andrew J, Uderhardt, Stefan, Chan, Waipan, Tsang, John S, Torabi-Parizi, Parizad, Fraser, Iain DC, Germain, Ronald N
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Computational and Systems Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684266/
https://ncbi.nlm.nih.gov/pubmed/31385572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46836
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