IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain incompletely defined. By stimulating mouse macrophages with a titration matrix of TLR ligand pairs, we...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Gottschalk, Rachel A, Dorrington, Michael G, Dutta, Bhaskar, Krauss, Kathleen S, Martins, Andrew J, Uderhardt, Stefan, Chan, Waipan, Tsang, John S, Torabi-Parizi, Parizad, Fraser, Iain DC, Germain, Ronald N
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Computational and Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684266/
https://ncbi.nlm.nih.gov/pubmed/31385572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46836
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